Will Graham's unusual, fearful ability to project himself into the minds of psychopaths puts him on the trail of Francis Dolorhyde, whose bizarre and bloody murders of two suburban families have been triggered by his viewing of a William Blake watercolor.

A serial murderer known only by a grotesquely apt nickname--Buffalo Bill--is stalking women. He has a purpose, but no one can fathom it, for the bodies are discovered in different states. Clarice Starling, a young trainee at the FBI Academy, is surprised to be summoned by Jack Crawford, chief of the Bureau's Behavioral Science section.

Her assignment: to interview Dr. Hannibal Lecter--Hannibal the Cannibal--who is kept under close watch in the Baltimore State Hospital for the Criminally Insane. Dr. Lecter is a former psychiatrist with a grisly history, unusual tastes, and an intense curiosity about the darker corners of the mind. His intimate understanding of the killer and of Clarice herself form the core of Thomas Harris.

Hannibal Lecter emerges from the nightmare of the Eastern Front, a boy in the snow, mute, with a chain around his neck. He seems utterly alone, but he has brought his demons with him. Hannibal’s uncle, a noted painter, finds him in a Soviet orphanage and brings him to France, where Hannibal will live with his uncle and his uncle’s beautiful and exotic wife, Lady Murasaki. Lady Murasaki helps Hannibal to heal.

With her help he flourishes, becoming the youngest person ever admitted to medical school in France. But Hannibal’s demons visit him and torment him. When he is old enough, he visits them in turn. He discovers he has gifts beyond the academic, and in that epiphany, Hannibal Lecter becomes death’s prodigy.