It was a dark and stormy night; Meg Murry, her small brother Charles Wallace, and her mother had come down to the kitchen for a midnight snack when they were upset by the arrival of a most disturbing stranger. "Wild nights are my glory," the unearthly stranger told them. "I just got caught in a downdraft and blown off course. Let me sit down for a moment, and then I'll be on my way. A Wrinkle in Time is the story of the adventures in space and time of Meg, Charles Wallace, and Calvin O'Keefe (athlete, student, and one of the most popular boys in high school). They are in search of Meg's father, a scientist who disappeared while engaged in secret work for the government on the tesseract problem.

Charles Wallace falls ill, and Meg, Calvin, and their teacher, Mr. Jenkins, must travel inside C.W. to make him well, and save the universe from the evil Echthros. It is November. When Meg comes home from school, Charles Wallace tells her he saw dragons in the twin's vegetable garden. That night Meg, Calvin and C.W. go to the vegetable garden to meet the Teacher (Blajeny) who explains that what they are seeing isn't a dragon at all, but a cherubim named Proginoskes. It turns out that C.W. is ill and that Blajeny and Proginoskes are there to make him well – by making him well, they will keep the balance of the universe in check and save it from the evil Echthros. Meg, Calvin and Mr. Jenkins (grade school principal) must travel inside C.W. to have this battle and save Charles' life as well as the balance of the universe.

fifteen-year-old Charles Wallace and the unicorn Gaudior undertake a perilous journey through time in a desperate attempt to stop the destruction of the world by the mad dictator Madog Branzillo. They are not alone in their quest. Charles Wallace's sister, Meg - grown and expecting her first child, but still able to enter her brother's thoughts and emotions by "kything" - goes with him in spirit.

Meg Murry, now in college, time travels with her twin brothers, Sandy and Dennys, to a desert oasis that is embroiled in war. Sandy and Dennys have always been the normal, run-of-the-mill ones in the extraodinary Murry family. They garden, make an occasional A in school, and play baseball. Nothing especially interesting has happened to the twins until they accidentally interrupt their father's experiment. Then the two boys are thrown across time and space. They find themselves alone in the desert, where, if they believe in unicorns, they can find unicorns, and whether they believe or not, mammoths and manticores will find them. The twins are rescued by Japheth, a man from the nearby oasis, but before he can bring them to safety, Dennys gets lost. Each boy is quickly embroiled in the conflicts of this time and place, whose populations includes winged seraphim, a few stray mythic beasts, perilous and beautiful nephilim, and small, long lived humans who consider Sandy and Dennys giants. The boys find they have more to do in the oasis than simply getting themselves home--they have to reunite an estranged father and son, but it won't be easy, especially when the son is named Noah and he's about to start building a boat in the desert.

While spending time with her grandparents, Alex and Kate Murry, Polly O'Keefe wanders into a time 3,000 years before her own. A flash of lightning, quivering ground, and, instead of her grandparents' farm, Polly sees mist and jagged mountains -- and coming toward her, a group of young men carrying spears. Why has a time gate opened and dropped Polly into a world that existed 3,000 years ago? Will she be able to get back to the present before the time gate closes -- and leaves her to face a group of people who believe in human sacrifice?