After the 1st wave, only darkness remains. After the 2nd, only the lucky escape. And after the 3rd, only theunlucky survive. After the 4th wave, only one rule applies: trust no one. Now, it's the dawn of the 5th wave, and on a lonely stretch of highway, Cassie runs from Them. The beings who only look human, who roam the countryside killing anyone they see. Who have scattered Earth's last survivors.

To stay alone is to stay alive, Cassie believes, until she meets Evan Walker. Beguiling and mysterious, Evan Walker may be Cassie's only hope for rescuing her brother--or even saving herself. But Cassie must choose: between trust and despair, between defiance and surrender, between life and death. To give up or to get up.

How do you rid the Earth of seven billion humans? Rid the humans of their humanity. Surviving the first four waves was nearly impossible. Now Cassie Sullivan finds herself in a new world, a world in which the fundamental trust that binds us together is gone. As the 5th Wave rolls across the landscape, Cassie, Ben, and Ringer are forced to confront the Others’ ultimate goal: the extermination of the human race. Cassie and her friends haven’t seen the depths to which the Others will sink, nor have the Others seen the heights to which humanity will rise, in the ultimate battle between life and death, hope and despair, love and hate.

Cassie, Ben, Ringer, and Evan confront the Others' plans for the fate of the human race and the planet.